Sympathetic activation but not dissociation linked to ketamine's sustained antidepressant effect.
Therapeutic Advances in Psychopharmacology 2026 Veronika Andrashko, Tomáš Novák, Miloslav Kopecek et al.
Ketamine is a rapid-acting antidepressant with robust evidence, but unclear predictors of therapeutic response. Based on previous knowledge, hemodynamic parameters and acute altered state of consciousness have been hypothesized as potential correlates of subsequent antidepressant outcome. A post hoc analysis was performed using the data from an open-label study, in which 39 patients with...