Effective treatments for prolonged disorders of consciousness (pDoC) remain limited. Grounded in the entropic brain hypothesis-that psychedelic agents facilitate consciousness recovery by increasing brain complexity-this study investigated esketamine, a nonclassical psychedelic drug, and its effects on electroencephalographic (EEG) neurophysiological metrics in pDoC patients. In this...
Auditory Evoked Potentials (AEP), particularly the N100 component and the auditory steady-state response (ASSR), have been utilized in the clinical assessment of patients with Disorders of Consciousness (DOC). However, the specific utility of these measures remains debated across studies. To clarify the roles of N100 and ASSR in evaluating auditory function and levels of consciousness in DOC...
Objective: Constructing a framework to evaluate consciousness is an important issue in neuroscience research and clinical practice. However, there is still no systematic framework for quantifying altered consciousness along the dimensions of both level and content. This study builds a framework to differentiate the following states: coma, general anesthesia, minimally conscious state (MCS), and...