Orexin signalling in the nucleus accumbens promotes arousal from isoflurane anaesthesia and restores communication between the nucleus accumbens and frontal cortex.
British Journal of Anaesthesia May 28, 2025 Jia Huo, Huiming Li, Dan Wang et al. 4 citations
Orexin can induce arousal from general anaesthesia; however, the underlying mechanisms are not fully understood. Nucleus accumbens (NAc), a downstream target of orexinergic neurones, plays a role in regulating consciousness. We aimed to clarify whether and how the NAc mediates the arousal effects of orexin. Fibre photometry was used to track changes of orexinergic afferent activity during...