247. DOES EXCITATORY/INHIBITORY BALANCE PREDICT KETAMINE RESPONSE IN TREATMENT-RESISTANT DEPRESSION? A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL WITH 1H-MRS
The International Journal of Neuropsychopharmacology August 1, 2025 Yuko Ohtani, Hiroe Tani, Shiori Honda et al.
Abstract Background Only 18-45% of individuals with treatment-resistant depression (TRD) respond to intravenous ketamine therapy. Although some neurobiological predictors of response to ketamine have been reported, none have been consistently replicated across multiple studies. The imbalance between glutamatergic excitatory and GABAergic inhibitory neurotransmissions is implicated in the...