Yoshihiro Noda

2 papers in the library · 3 citations · publishing 2025

Papers

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Glutamate plus glutamine to GABA ratio as a predictor of ketamine response in treatment-resistant depression: A double-blind, randomized, open-label extension study.

Journal of Affective Disorders August 15, 2025 Yohei Ohtani, Hideaki Tani, Shiori Honda et al. 3 citations

Approximately 30 % of patients with treatment-resistant depression (TRD) respond to ketamine; however, no replicable predictors of response have been reported. The imbalance between excitatory and inhibitory neurotransmissions may be implicated in the mechanism of action of ketamine. This study aimed to evaluate whether the ratio of glutamate and glutamine (Glx) to GABA levels at baseline in...

DOI: 10.1016/j.jad.2025.04.165 Full text Treatment-resistant depression 1h-mrs Excitatory/inhibitory balance Gaba +6

247. DOES EXCITATORY/INHIBITORY BALANCE PREDICT KETAMINE RESPONSE IN TREATMENT-RESISTANT DEPRESSION? A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL WITH 1H-MRS

The International Journal of Neuropsychopharmacology August 1, 2025 Yuko Ohtani, Hiroe Tani, Shiori Honda et al.

Abstract Background Only 18-45% of individuals with treatment-resistant depression (TRD) respond to intravenous ketamine therapy. Although some neurobiological predictors of response to ketamine have been reported, none have been consistently replicated across multiple studies. The imbalance between glutamatergic excitatory and GABAergic inhibitory neurotransmissions is implicated in the...

DOI: 10.1093/ijnp/pyaf052.202 Ketamine Treatment-resistant depression Major depressive disorder Inhibitory postsynaptic potential +6