Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.
Cell April 30, 2026 Hermany Munguba, Anisul Arefin, Ryota Hasegawa et al. 4 citations
Depression is driven by dysfunction in discrete neural circuits, but a deeper understanding of the underlying molecular and synaptic mechanisms is needed to guide the development of therapeutics. Here, we decipher the mechanisms of action of the fast-acting antidepressant ketamine to enable the identification of G protein-coupled receptor (GPCR) antidepressant targets. We find that the...