A comprehensive review of the clinical progress of esketamine: From anesthesia to antidepressant therapy.
Medicine May 1, 2026 Hai-Lin Hu, Qi-Zhou Huang, Ping-Xia Xie
Esketamine, the S-enantiomer of ketamine, has emerged as a rapid-acting antidepressant with unique mechanisms. This narrative review synthesizes current evidence on its clinical applications, safety, and regulatory status based on peer-reviewed literature published between January 2000 and March 2024, searched in PubMed, Web of Science, and the Cochrane Library. Esketamine exerts its effects...
DOI: 10.1097/md.0000000000048570 (opens in new tab)
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Esketamine
Treatment-resistant depression
Nmda receptor
Anesthesia
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