TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine.
Science Advances May 1, 2026 Anisul Arefin, Jihye Kim, Manas Pratim Chakraborty et al. 1 citation
A complex ensemble of neuromodulatory receptors orchestrates the many forms of synaptic plasticity that drive behavioral state changes, but an understanding of how such receptors functionally interact is limited. Here, we find that the antidepressant action of ketamine is dependent on both the receptor tyrosine kinase, tropomyosin-related kinase B (TrkB), and the G protein-coupled receptor,...