Distinct effects of global signal regression on brain activity during propofol and sevoflurane anesthesia.
Frontiers in Neuroscience 2025 Fa Lu, Lunxu Li, Juan Wang et al.
Global signal regression (GSR) is widely used in functional magnetic resonance imaging (fMRI) analysis, yet its effects on anesthetic-related brain activity are not well understood. Using fMRI data from patients under general anesthesia, we analyzed temporal variability indices, amplitude of low-frequency fluctuations, functional connectivity, and graph theoretical measures with and without...