Marianne B. Müller

2 papers in the library · 9 citations · publishing 2017-2020

Papers

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Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration

International Journal of Molecular Sciences March 20, 2020 David P. Herzog, Ratnadevi M. Mellema, Floortje Remmers et al. 9 citations

Background: Rapid-acting antidepressants ketamine and (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) have overcome some of the major limitations of classical antidepressants. However, little is known about sex-specific differences in the behavioral and molecular effects of ketamine and (2R,6R)-HNK in rodents. Methods: We treated mice with an intraperitoneal injection of either saline, ketamine (30 mg...

DOI: 10.3390/ijms21062142 Ketamine Anxiety Arc geometry Behavioural despair test +11

Ketamine's antidepressant effect is mediated by energy metabolism and antioxidant defense system.

Scientific Reports November 17, 2017 Katja Weckmann, Michael J Deery, Julie A Howard et al.

Fewer than 50% of all patients with major depressive disorder (MDD) treated with currently available antidepressants (ADs) show full remission. Moreover, about one third of the patients suffering from MDD does not respond to conventional ADs and develop treatment-resistant depression (TRD). Ketamine, a non-competitive, voltage-dependent N-Methyl-D-aspartate receptor (NMDAR) antagonist, has been...

DOI: 10.1038/s41598-017-16183-x Full text