John M Asara

Ketamine's antidepressant effect is mediated by energy metabolism and antioxidant defense system.

Scientific Reports November 17, 2017 Katja Weckmann, Michael J Deery, Julie A Howard et al.

Fewer than 50% of all patients with major depressive disorder (MDD) treated with currently available antidepressants (ADs) show full remission. Moreover, about one third of the patients suffering from MDD does not respond to conventional ADs and develop treatment-resistant depression (TRD). Ketamine, a non-competitive, voltage-dependent N-Methyl-D-aspartate receptor (NMDAR) antagonist, has been...