Repeated Dosing of Ketamine in the Forced Swim Test: Are Multiple Shots Better Than One?
Frontiers in Psychiatry May 11, 2021 Ridge G. Weston, Paul J. Fitzgerald, Brendon O. Watson 19 citations
The anesthetic drug ketamine has been successfully repurposed as an antidepressant in human subjects. This represents a breakthrough for clinical psychopharmacology, because unlike monoaminergic antidepressants, ketamine has rapid onset, including in Major Depressive Disorder (MDD) that is resistant to conventional pharmacotherapy. This rapid therapeutic onset suggests a unique mechanism of...