Samara Machado Bruck

Ketamine-induced NMDA receptor hypofunction alters social and locomotor behavior in adult zebrafish

bioRxiv (Cold Spring Harbor Laboratory) September 17, 2025 Matheus Gallas‐lopes, Dagobert Müller, Thailana Stahlhofer-Buss et al. preprint

ABSTRACT Background NMDA receptor antagonists, such as ketamine, are widely used to model schizophrenia-related phenotypes in preclinical studies. While zebrafish have emerged as a promising model organism for neuropsychiatric research, few studies have characterized their behavioral responses to repeated ketamine exposure. Methods Three independent experiments were conducted to evaluate the...