Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade
Frontiers in Molecular Neuroscience September 11, 2015 Elena Enosyreva, Anita E. Autry, Ege Ekavalali et al. 51 citations
Ketamine is a NMDA receptor antagonist that produces rapid antidepressant responses in individuals with major depressive disorder. The antidepressant action of ketamine has been linked to blocking NMDA receptor activation at rest, which inhibits eukaryotic elongation factor2 kinase leading to desuppression of protein synthesis and synaptic potentiation in the CA1 region of the hippocampus....