Increased brain VDAC1 protein levels correlate with behavioural performance in a ketamine murine model of schizophrenia and are attenuated by the mGluR2 modulator JNJ-46356479.
Schizophrenia Research June 16, 2026 David Olivares-Berjaga, Natàlia Rodríguez, Albert Martínez-pinteño et al.
Schizophrenia (SZ) is a neurodevelopmental disorder involving excitatory/inhibitory imbalance and apoptotic dysregulation. VDAC1, a voltage-dependent anion channel protein located in the mitochondrial outer membrane, plays a pivotal role in mitochondria-mediated apoptosis. However, its involvement in SZ remains underexplored. This study aimed to investigate VDAC1 protein levels in the...
DOI: 10.1016/j.schres.2026.06.010 (opens in new tab)
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Ketamine
Apoptosis
Jnj-46356479
Murine model
+1