BMJ OpenSeptember 22, 2026Anna Kristina Eigenbrodt, Poul P Laigaard, Melika Hassani et al.
Recovery of consciousness after brain injury remains a major challenge in the intensive care unit (ICU), and pharmacological treatments that directly promote awakening from coma and other disorders of consciousness (DoC) are lacking. We hypothesise that simultaneously targeting the two core components of consciousness by pharmacological means-arousal with apomorphine and awareness with...
BrainJune 12, 2025Marwan H Othman, Attila Géry Toury-Puel, Karen Irgens Tanderup Hansen et al.7 citations
In the intensive care unit (ICU), management of unresponsive patients with brain injury focuses on preventing secondary brain damage. Therapeutic strategies that directly promote the recovery of consciousness are urgently needed. In an investigator-initiated, randomized, placebo-controlled, double-blind, cross-over trial, we studied the effects of apomorphine and methylphenidate in ICU patients...