Fernando A. N. Santos

An exploratory persistent-homology analysis of resting-state fMRI functional connectivity under Ayahuasca

Chaos Solitons & Fractals May 30, 2026 Tales Ramos Monteiro Dos Santos, Draulio B Araujo, Helcio Felippe et al.

Psychedelic states offer a useful setting for studying changes in large-scale brain organization. Here, we applied Topological Data Analysis (TDA) to resting-state fMRI functional connectivity from nine participants scanned before and after Ayahuasca ingestion. Vietoris–Rips filtrations were constructed from correlation-derived dissimilarity matrices, and persistent entropy was used to quantify...