Animal models in psychedelic research – Tripping over translation
bioRxiv Preprint Server January 14, 2026 Muad Y. Abd El Hay, Ana Cukić, Marieke L. Schölvinck et al. preprint
Psychedelic substances show promise for treating psychiatric disorders including depression, anxiety, and PTSD, but the neurobiological mechanisms underlying their therapeutic effects remain poorly understood. Preclinical findings have so far been inconsistent, limiting mechanistic insights. We argue this translational gap is exacerbated by systematic disconnects between conditions thought to...