Christopher R. Means

2 papers in the library · 99 citations · publishing 2021

Papers

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LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1

Scientific Reports September 5, 2021 Ramona M. Rodriguiz, Vineet Nadkarni, Christopher R. Means et al. 92 citations

Abstract Recent evidence suggests that psychedelic drugs can exert beneficial effects on anxiety, depression, and ethanol and nicotine abuse in humans. However, their hallucinogenic side-effects often preclude their clinical use. Lysergic acid diethylamide (LSD) is a prototypical hallucinogen and its psychedelic actions are exerted through the 5-HT2A serotonin receptor (5-HT2AR). 5-HT2AR...

DOI: 10.1038/s41598-021-96736-3 Full text

LSD’s effects are differentially modulated in arrestin knockout mice

bioRxiv Preprint Server February 4, 2021 Ramona M. Rodriguiz, Vineet Nadkarni, Christopher R. Means et al. 7 citations preprint

Recent evidence suggests that psychedelic drugs can exert beneficial effects on anxiety, depression, and ethanol and nicotine abuse in humans. However, the hallucinogenic side-effects of psychedelics often preclude their clinical use. Lysergic acid diethylamide (LSD) is a prototypical hallucinogen and its psychedelic actions are exerted through the 5-HT2A serotonin receptor (5-HT2AR). 5-HT2AR...

DOI: 10.1101/2021.02.04.429772 Full text