Serotonergic modulation of excitatory synapse development and plasticity
Molecules and Cells March 10, 2026 Victoria N. Chang, Roberto Ogelman, R. Vargas et al. 1 citation
Excitatory synapse plasticity at postsynaptic dendritic spines is directly modulated through neurotransmitter signaling. Serotonin (5-HT) is a primary neuromodulator in the brain that activates 14 subtypes of G-protein-coupled receptors, each with distinct expression patterns and downstream signaling mechanisms. Disruptions of serotonergic transmission during development and adulthood induce...