Whole-brain drug distribution profiles of psychedelic drugs provide insights into rapid antidepressant action
bioRxiv (Cold Spring Harbor Laboratory) April 7, 2026 Benjamin Hänisch, Tobias Kaufmann, Sofie L. Valk
Recent studies pioneered the use of classic hallucinogens as Rapid-Acting Antidepressants (RAAD). To further understand the link between their neuromodulatory and antidepressant effects, we combine pharmacodynamic profiles of four classic hallucinogens and the anaesthetic Ketamine with receptor density distributions from both Positron Emission Tomography (PET) and layer-resoluted...