Enhanced effect of the hallucinogen DOI in L-DOPA receptor Gpr143-deficient mice.
Journal of Pharmacological Sciences June 1, 2026 Daiki Masukawa, Rei Tajika, Yoshimi Ichimaru et al.
Hallucinogens, such as lysergic acid diethylamide, act primarily through the 5-hydroxytryptamine 2A (5-HT2A) receptor, but their regulatory mechanisms remain unclear. G protein-coupled receptor 143 (GPR143), an L-3,4-dihydroxyphenylalanine (L-DOPA) receptor, modulates specific GPCRs. We examined the role of GPR143 in the action of 5-HT2A receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI)....
DOI: 10.1016/j.jphs.2026.04.002 (opens in new tab)
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5-ht2a receptor
2,5-dimethoxy-4-iodoamphetamine
Gpr143