LSD persistently disrupts affective pain processing.
bioRxiv : the preprint server for biology May 11, 2026 Jared Plotkin, Elaine Zhu, Mélanie Druart et al.
Psychedelics produce long-lasting effects, but their circuit mechanisms remain unclear. Here we show that, in rats, a single dose of lysergic acid diethylamide (LSD) persistently reduces pain affect. This effect is recapitulated by local administration in the anterior cingulate cortex (ACC), but not primary somatosensory cortex. Neuropixels recordings reveal that LSD suppresses stimulus-evoked...