Spatial collinearity constrains multivariate molecular-enriched network estimation.
bioRxiv : the preprint server for biology June 12, 2026 Timothy Lawn, Johan Nakuci, Steve Cr Williams et al.
Analyses of neuroimaging data increasingly leverage the distribution of neurotransmitter receptors derived from Positron Emission Tomography (PET) to bridge the gap between micro- and macro-scale brain function. However, these receptor maps are highly spatially overlapping which can give rise to interpretive and analytical challenges. Here, we systematically investigate the impact of spatial...