Tripping on context: Characteristics and predictors of placebo and nocebo psychedelic effects
medRxiv Preprint Server May 31, 2026 Madeline V. Stein, Matt Butler, Sarah Chapman et al. preprint
Psychedelic drugs are emerging as potentially efficacious tools for treating psychiatric conditions and probing the neural basis of consciousness. Although drug administration context is widely believed to shape psychedelic effects, it remains unclear whether it can independently generate placebo and nocebo effects resembling psychedelic experiences and side effects. In a pre-registered...