Sex-specific increased reactivity of the PVT and prolonged PVT→CeA circuit engagement following psilocin administration.
Nature Communications April 10, 2026 Devin P. Effinger, J L Hoffman, Sema G. Quadir et al. 1 citation
The psychedelic psilocybin has shown therapeutic potential, yet underlying neural mechanisms remain poorly understood. We investigated the impact of psilocin-the active metabolite of psilocybin-on basal activity and reactivity within the paraventricular nucleus of the thalamus (PVT) and PVT projections to central amygdala (CeA) in rats. Psilocin administration increased PVT c-Fos expression and...