Effects of a single dose of psilocybin on diet-induced weight loss in obese mice.
Translational Psychiatry April 14, 2026 Ryan J. Keenan, Rifa T Haque, Xiangjun Jin et al.
Prolonged obesity induces enduring structural changes within neural circuits that contribute to maintaining the body at an elevated/obese body weight. These circuits regulate various mechanisms which can inhibit extreme or persistent weight loss. Therefore, a potential therapeutic strategy to facilitate weight loss is to promote structural plasticity within the brain. Psychedelic compounds,...