New Antidepressant Development in the Treatment of Depression.
Advances in experimental medicine and biology 2026 Alessandro Spiti, Daniela Caldirola, Giampaolo Perna 1 citation
Major depressive disorder (MDD) continues to pose a major therapeutic challenge due to its clinical heterogeneity. This chapter looks at the development of antidepressant treatments, starting with early interventions such as electroconvulsive therapy (ECT), monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs). Although these treatments targeted the monoaminergic system,...