Polysubstance use involving psychostimulants and opioids is increasingly prevalent and associated with elevated overdose risk, relapse vulnerability, and poor treatment outcomes. However, the neurobehavioral consequences of opioid-stimulant use remain poorly understood. We evaluated whether repeated methamphetamine-fentanyl polysubstance treatment disrupts social preference during withdrawal,...
Polysubstance use of opioids and stimulants is increasingly common among individuals with a substance use disorder, yet most researchers examine these substances in isolation. This gap limits our understanding of the effects of polysubstance use and how these differ from single substance use. Here, we examined the impact of single versus polysubstance exposure of fentanyl and methamphetamine on...