Joe Xavier Simonet

Transient multidomain functional improvement in advanced Alzheimer's disease following high-dose psilocybin-containing mushroom administration: a case report.

Frontiers in Neuroscience 2026 Marcos Lago, Mariana Cerveira, Joe Xavier Simonet 1 citation

Advanced Alzheimer's disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking. We report the case of an octogenarian Japanese-American woman with a 10-year history of...