Transient multidomain functional improvement in advanced Alzheimer's disease following high-dose psilocybin-containing mushroom administration: a case report.
Frontiers in Neuroscience 2026 Marcos Lago, Mariana Cerveira, Joe Xavier Simonet 1 citation
Advanced Alzheimer's disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking. We report the case of an octogenarian Japanese-American woman with a 10-year history of...
DOI: 10.3389/fnins.2026.1813281 (opens in new tab)
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Neuroplasticity
Psilocybin
Alzheimer’s disease
Advanced dementia
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