No evidence for direct physical interaction of 5-HT 2A -mGluR2 receptors in vitro or in vivo
bioRxiv (Cold Spring Harbor Laboratory) June 30, 2026 Blake A Fordyce, Yi-Ting Chiu, Nicholas A. Wright et al.
Abstract Activation of mGluR2 (metabotropic glutamate receptor 2), the primary presynaptic autoreceptor for glutamate in the brain, is well established to attenuate the psychedelics-mediated behavioral and electrophysiological effects. However, the mechanisms responsible for these actions are controversial. The two competing mechanistic hypotheses have been proposed to explain this phenomenon...