Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine
National Science Review September 5, 2025 Huoqing Luo, Ming Chen, Yingjie Ning et al. 1 citation
-methyl-d-aspartate receptor (NMDAR) blockade is crucial for the rapid antidepressant effects of ketamine, the involvement of other mechanisms remains contentious, particularly regarding the role of serotonin, a key neurotransmitter in the target of traditional antidepressants. Here, we demonstrate that ketamine elevates serotonin levels by inhibiting the serotonin transporter (SERT). A...