A microdosing approach for characterizing formation and repair of carboplatin–DNA monoadducts and chemoresistance
International Journal of Cancer December 2, 2010 Paul T. Henderson, Tao Li, Miaoling He et al. 37 citations
Formation and repair of platinum (Pt)-induced DNA adducts is a critical step in Pt drug-mediated cytotoxicity. Measurement of Pt-DNA adduct kinetics in tumors may be useful for better understanding chemoresistance and therapeutic response. However, this concept has yet to be rigorously tested because of technical challenges in measuring the adducts at low concentrations and consistent access to...