Predicting Drug Candidate Victims of Drug-Drug Interactions, using Microdosing
Clinical Pharmacokinetics February 16, 2012 Marie Croft, Brendan J. Keely, Ian D. Morris et al. 42 citations
ObjectiveThe aim of this crossover human male volunteer study was to investigate the utility of microdosing in the investigation of drug-drug interactions.MethodsA mixture of midazolam, tolbutamide, caffeine and fexofenadine were administered as a microdose (25 μg each) before and after administration of a combined pharmacological dose of ketoconazole (400 mg) and fluvoxamine (100 mg) to...