Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs
Clinical Pharmacology & Therapeutics September 1, 2006 Graham Lappin, W. Kuhnz, R. Jochemsen et al. 242 citations
OBJECTIVES: A volunteer trial was performed to compare the pharmacokinetics of 5 drugs--warfarin, ZK253 (Schering), diazepam, midazolam, and erythromycin--when administered at a microdose or pharmacologic dose. Each compound was chosen to represent a situation in which prediction of pharmacokinetics from either animal or in vitro studies (or both) was or is likely to be problematic. METHODS: In...