Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development
European Journal of Clinical Pharmacology September 1, 2003 Mats Bergstr�m, A. Grahn�n, B. L�ngstr�m 312 citations
The realisation that new chemical entities under development as drug candidates fail in three of four cases in clinical trials, together with increased costs and increased demands of reducing preclinical animal experiments, have promoted concepts for improvement of early screening procedures in humans. Positron emission tomography (PET) is a non-invasive imaging technology, which makes it...