Investigating the Mechanisms of Esketamine in Treating Propofol-Induced Cognitive Impairment in Elderly Rats.
Discovery medicine April 1, 2025 Jieru Zhang, Guofeng Xu, Xiaoli Wang et al.
Common cognitive impairment in the elderly may be aggravated by the anesthetic propofol, whereas the mammalian target of rapamycin protein (mTOR)-brain-derived neurotrophic factor (BDNF) pathway and autophagy regulation play a key role in neuroprotection. In this study, we investigated whether esketamine can improve propofol-induced cognitive impairment in aged rats by affecting these...
DOI: 10.24976/Discov.Med.202537195.60 (opens in new tab)
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Esketamine
Mtor-bdnf pathway
Neuronal autophagy
Postoperative cognitive dysfunction
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