Ketamine and Midazolam Neurotoxicity in the Rabbit
Anesthesiology July 1, 1991 Jean-Marc Malinovsky, A. Cozian, Jean-Yves Lepage et al. 244 citations
Ketamine and midazolam can produce analgesia following intrathecal administration in rabbits. However, neurotoxicity studies are required before these agents can be considered safe for clinical use. The aim of this study was to evaluate by histologic and blood-brain barrier (BBB) studies whether ketamine or midazolam could be used as an alternative to local anesthetics or opioids to produce...