Glutamate and the Neural Basis of the Subjective Effects of Ketamine
Archives of General Psychiatry February 1, 2008 J.f.w. Deakin, Jane Lees, Shane Mckie et al. 315 citations
CONTEXT: Ketamine evokes psychosislike symptoms, and its primary action is to impair N-methyl-D-aspartate glutamate receptor neurotransmission, but it also induces secondary increases in glutamate release. OBJECTIVES: To identify the sites of action of ketamine in inducing symptoms and to determine the role of increased glutamate release using the glutamate release inhibitor lamotrigine....