BDNF Release Is Required for the Behavioral Actions of Ketamine
The International Journal of Neuropsychopharmacology October 31, 2014 Ashley E. Lepack, Manabu Fuchikami, J. M. Dwyer et al. 369 citations
BACKGROUND: Recent studies demonstrate that the rapid antidepressant ketamine increases spine number and function in the medial prefrontal cortex (mPFC), and that these effects are dependent on activation of glutamate α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors and brain-derived neurotrophic factor (BDNF). In vitro studies also show that activation of AMPA receptors...