Remifentanil-induced Postoperative Hyperalgesia and Its Prevention with Small-dose Ketamine
Anesthesiology June 27, 2005 Vincent Joly, Philippe Richebé, B. Guignard et al. 624 citations
BACKGROUND: Remifentanil-induced secondary hyperalgesia has been documented experimentally in both animals and healthy human volunteers, but never clinically. This study tested the hypotheses that increased pain sensitivity assessed by periincisional allodynia and hyperalgesia can occur after relatively large-dose intraoperative remifentanil and that small-dose ketamine prevents this...