Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings)
CNS Neuroscience & Therapeutics April 10, 2013 G. Mion, Thierry Villevieille 690 citations
For more than 50 years, ketamine has proven to be a safe anesthetic drug with potent analgesic properties. The active enantiomer is S(+)-ketamine. Ketamine is mostly metabolized in norketamine, an active metabolite. During "dissociative anesthesia", sensory inputs may reach cortical receiving areas, but fail to be perceived in some association areas. Ketamine also enhances the descending...