Psilocin glucuronide in whole blood: a stable and useful biomarker of psilocybin intake
Journal of Analytical Toxicology February 19, 2026 Marianne Skov-Skov Bergh, Inger Lise Bogen, Merete Vevelstad et al.
Detecting psilocybin use is challenging because it rapidly converts to its psychoactive metabolite psilocin, and both compounds are unstable in blood. Bufotenin, a structural isomer of psilocin, may exhibit comparable instability in blood. For reliable detection, we developed and validated an LC-MS/MS method to simultaneously quantify psilocin, bufotenin, and their metabolites, psilocin...