Current pharmacotherapies for post-traumatic stress disorder (PTSD) are limited by delayed onset and side effects. Despite ketamine exhibiting rapid relief of the core symptoms of PTSD, its clinical efficacy varies considerably depending on the timing of drug delivery. However, the underlying mechanism remains unclear. In this study, the therapeutic effects of early (day 1) and late (day 7)...
Electrophysiological studies revealed that different neuronal oscillations, among which the alpha (8-13 Hz) rhythm in particular, but also the beta (13-30 Hz) and gamma (30-80 Hz) rhythms, are modulated during rest in the default mode network (DMN). Little is known, however, about the role of these rhythms in supporting DMN connectivity. Biophysical studies suggest that lower and higher...