Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics
PLoS Computational Biology December 15, 2025 Lingyu Zhang, Weiyang Shi, Ziyang Zhao et al.
Lysergic acid diethylamide (LSD) has shown remarkable potential in modulating brain functional organization and dynamics. However, the exact mechanisms underlying its effects remain unclear. In this study, we employed a data-driven approach to analyze recurrent functional connectivity patterns in resting-state fMRI data and developed a parameterized feedback inhibition model to characterize...