The Effects of the Preferential 5-HT2A Agonist Psilocybin on Prepulse Inhibition of Startle in Healthy Human Volunteers Depend on Interstimulus Interval
Neuropsychopharmacology February 14, 2007 Franz X. Vollenweider, Philipp A Csomor, Bernhard Knappe et al. 194 citations
Schizophrenia patients exhibit impairments in prepulse inhibition (PPI) of the startle response. Hallucinogenic 5-HT(2A) receptor agonists are used for animal models of schizophrenia because they mimic some symptoms of schizophrenia in humans and induce PPI deficits in animals. Nevertheless, one report indicates that the 5-HT(2A) receptor agonist psilocybin increases PPI in healthy humans....
DOI: 10.1038/sj.npp.1301324 (opens in new tab)
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Psilocybin
Prepulse inhibition
Hallucinogen
Interstimulus interval
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