Adrienne Umali

2 papers in the library · 122 citations · publishing 2012-2013

Papers

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Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System

Journal of Neuroscience January 16, 2013 Terrell Holloway, José L. Moreno, Adrienne Umali et al. 122 citations

It has been suggested that severe adverse life events during pregnancy increase the risk of schizophrenia in the offspring. The serotonin 5-HT 2A and the metabotropic glutamate 2 (mGlu2) receptors both have been the target of considerable attention regarding schizophrenia and antipsychotic drug development. We tested the effects of maternal variable stress during pregnancy on expression and...

DOI: 10.1523/jneurosci.2331-12.2013 Full text Serotonin Offspring Metabotropic receptor Metabotropic glutamate receptor +5

Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice

Psychopharmacology July 28, 2012 J. Moreno, Terrell Holloway, Adrienne Umali et al.

In schizophrenia patients, optimal treatment with antipsychotics requires weeks to months of sustained drug therapy. However, single administration of antipsychotic drugs can reverse schizophrenia-like behavioral alterations in rodent models of psychosis. This raises questions about the physiological relevance of such antipsychotic-like activity. This study evaluates the effects of chronic...

DOI: 10.1007/s00213-012-2809-7 Full text