Mária Simon

Novel drug developmental strategies for treatment‐resistant depression

British Journal of Pharmacology November 25, 2021 Éva Borbély, Mária Simon, Eberhard Fuchs et al. 103 citations

Major depressive disorder is a leading cause of disability worldwide. Because conventional therapies are ineffective in many patients, novel strategies are needed to overcome treatment‐resistant depression (TRD). Limiting factors of successful drug development in the last decades were the lack of (1) knowledge of pathophysiology, (2) translational animal models and (3) objective diagnostic...