Carolina M. Camargo

Neuronal Population Effects of Ketamine on Human Brain Organoids

bioRxiv (Cold Spring Harbor Laboratory) March 10, 2026 Arina Nikitina, Christian Bustamante Toro, Raymond Gifford et al. preprint

Abstract Ketamine’s rapid neuropsychiatric actions emerge from interactions that span receptors, cells, and circuits, but their net effects on human neuronal population dynamics remain incompletely defined. Here we combine human dorsal forebrain organoids with high-density microelectrode arrays (MEAs) to quantify ketamine’s effects from spikes to networks. In 6-month-old organoids, acute...